Domenica Regazzoni was born in Valsassina (Lecco) in 1953 and began painting in the early 1970s while attending the Brera Academy in Milan.
In the 1990s, she transitioned from figurative painting to a more abstract and informal approach. In 1992, she illustrated Canto Segreto (Secret Song), a collection of poems by Antonia Pozzi, for Vanni Scheiwiller’s series All’insegna del Pesce d’Oro (Under the Sign of the Golden Fish). Inspired by the most poetic songs of Mogol and Lucio Dalla, she held her first exhibitions: Colore Incanto (Color Enchantment) in 1996 and Regazzoni & Dalla in 1998.
Between 1997 and 2001, she held solo exhibitions in Tokyo and in numerous Italian cities, including Milan at the Fondazione Stelline, Rome at the Complesso del Vittoriano, Bergamo at the Centro Culturale San Bartolomeo, and Bologna in the former church of San Mattia.
In 2000, she published a monograph inspired by Haiku poetry, edited by Viennepierre.
Following the passing of her father, she created the exhibition Dal Legno al Suono (From Wood to Sound), curated by Gillo Dorfles, with a catalog by Skira. This exhibition was displayed at Palazzo Vecchio in Florence (2003), Teatro Dal Verme in Milan (2004), Villa Manzoni in Lecco (2005), and the Auditorium Parco della Musica in Rome (2006).
In 2008, she presented the exhibition Scolpire la musica (Sculpting Music), curated by Martina Corgnati, with a catalog by Skira, at Bocconi University in Milan, the International Museum and Library of Music in Bologna, and the Galerie Miyawaki in Kyoto.
Starting in 2007, she began working in the field of printmaking at the Giorgio Upiglio print shop.
Between 2010 and 2011, she held the exhibition Ultime luci: Sestri 1980–1990 (Last Lights: Sestri 1980–1990), curated by Stefano Crespi, at the Municipal Palace of Sestri Levante.
In 2011, she participated in the 54th edition of the Venice Biennale, and the following year she exhibited a series of works inspired by Milan, featuring photographs by Gabriele Basilico, as part of the project “La fabbrica e la città” (The Factory and the City). In the same year, she collaborated with government cultural institutions in Shanghai, presenting solo exhibitions at the Italian Shanghai Center and the Faculty of Architecture at Tongji University. In 2014 and 2017, she participated in the second and third Rome Triennale.
In 2015, as part of Milano Expo in Città, she exhibited Convergenze Parallele (Parallel Convergences), curated by Ivan Quaroni, with a catalog by Allemandi, at Palazzo della Permanente in Milan.
In 2020, she exhibited Domenica Regazzoni & Lucio Dalla a 4 mani (Domenica Regazzoni & Lucio Dalla Four Hands), curated by Silvia Evangelisti at Palazzo d’Accursio in Bologna, at the invitation of the Municipality of Bologna and the Dalla Foundation. A large selection of these works was showcased again at Rome Arte in Nuvola in 2021.
Since 2009, her large bronze sculpture, Violino spaccato (Broken Violin), has been on permanent display in the square of the University of Bucharest. Since 2019, her monumental sculpture, Fiore di violino (Violin Flower), presented by Angelo Crespi, has been placed in Barzio (Lecco), in front of the headquarters of the Mountain Community Authority. Other public works are permanently displayed in Segrate (Milan) in Piazza San Francesco and in Vieste (Foggia) in the Court of the Élite located within the Town Hall.